Syllabus: H GEN 658: Genome Science Core Course

1. Genome Biology
   1. Sequence variation and evolution
      1. Mutation
      2. Rearrangements
      3. Recombination
      4. Gene conversion
   2. Chromosomes
      1. Structure
      2. Mechanics
   3. Physical mapping
      1. Libraries
      2. Contigs
   4. Genotyping
2. Genome Informatics
   1. Databases
   2. Feature finding
      1. Approaches
         1. Domain matching
         2. Neural nets
      2. Gene finding
      3. Regulatory sequences
   3. Genetic analysis
3. Instrumentation
   1. Fluorescence detection
   2. Probing devices
   3. Fluid phase methods --- microfluidics
   4. Solid phase methods
      1. Magnetic beads
      2. Silicon chip technology
         1. Microchemistry
         2. Hybridization
   5. Gas phase methods --- mas spectrometry
4. Automation and Robotics
   1. Machine integration
      1. Process flow
      2. Feedback control
   2. Robots
      1. Off the shelf
      2. Custom robots
      3. Microrobots
5. Ethical, Legal and Social Implications